Data from any test that the applicant reasonably correlates to the asserted utility should be evaluated substantively. The examiner should also ensure that there is an adequate nexus between the evidence and the properties of the now claimed subject matter as disclosed in the application as filed. Successful in vitro testing will marshal resources and direct the expenditure of effort to further in vivo testing of the most potent compounds, thereby providing an immediate benefit to the public, analogous to the benefit provided by the showing of an in vivo utility. ClinOrthopRelatRes. 2001;385:176–181. [PubMed]29. Kato K, Aoki H, Tabata T, Ogiso M. Biocompat-ibility of apatite ceramics in mandibles. Other DNA bands were amplified in nearly all of the BAC DNA pools as well as from sorghum genomic DNA. These products most likely originate from repetitive sequences scattered throughout the sorghum genome.
Therefore, SAS-DNA markers identify overlapping BACs in a manner similar to other single copy markers. The absence of a certification that the test in question is an industry-accepted model is not dispositive of whether data from an animal model is in fact relevant to the asserted utility. Contigs organized using only fingerprint data or solely using PCR-based screening of BAC pools resulted in a low but significant error rate. To reduce this source of error, BACs were incorporated into the sorghum physical map only when their order or location was verified by two different analyses.
Each pool contained approx. 100 ml of culture. Spine. 2003;28(17):1954–60. [PubMed]18. Lehman RA, Jr., Kuklo TR, Freedman BA, et al. Utilities that require or constitute carrying out further research to identify or reasonably confirm a “real world” context of use are not substantial utilities. Even at this early stage of map development, a significant number AFLP markers found linked to a new locus have already been mapped, and in many cases a contig of linked BACs has been identified.